LymphedemaV1, Main, Exploration, bibRecord, 003294

Population Genetics of the Filarial Worm Wuchereria bancrofti in a Post-treatment Region of Papua New Guinea: Insights into Diversity and Life History

Identifieur interne : 003294 ( Main/Exploration ); précédent : 003293; suivant : 003295

Population Genetics of the Filarial Worm Wuchereria bancrofti in a Post-treatment Region of Papua New Guinea: Insights into Diversity and Life History

Auteurs : Scott T. Small [États-Unis] ; Akshaya Ramesh [États-Unis] ; Krufinta Bun [États-Unis] ; Lisa Reimer [États-Unis, Papouasie-Nouvelle-Guinée] ; Edward Thomsen [États-Unis, Papouasie-Nouvelle-Guinée] ; Manasseh Baea [Papouasie-Nouvelle-Guinée] ; Moses J. Bockarie [États-Unis, Papouasie-Nouvelle-Guinée, Royaume-Uni] ; Peter Siba [Papouasie-Nouvelle-Guinée] ; James W. Kazura [États-Unis] ; Daniel J. Tisch [États-Unis] ; Peter A. Zimmerman [États-Unis]

Source :

PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2013.

RBID : PMC:3708868

Descripteurs français

KwdFr :
- ADN des helminthes (), ADN des helminthes (génétique), Adolescent, Adulte, Analyse de séquence d'ADN, Animaux, Complexe IV de la chaîne respiratoire (génétique), Données de séquences moléculaires, Enfant, Femelle, Filariose lymphatique (parasitologie), Filariose lymphatique (épidémiologie), Haplotypes, Helminthes (), Helminthes (génétique), Helminthes (isolement et purification), Humains, Jeune adulte, Mâle, Papouasie - Nouvelle-Guinée (épidémiologie), Protéines mitochondriales (génétique), Variation génétique, Wuchereria bancrofti (), Wuchereria bancrofti (génétique), Wuchereria bancrofti (isolement et purification).
MESH :
- génétique : ADN des helminthes, Complexe IV de la chaîne respiratoire, Helminthes, Protéines mitochondriales, Wuchereria bancrofti.
- isolement et purification : Helminthes, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- épidémiologie : Filariose lymphatique, Papouasie - Nouvelle-Guinée.
- ADN des helminthes, Adolescent, Adulte, Analyse de séquence d'ADN, Animaux, Données de séquences moléculaires, Enfant, Femelle, Haplotypes, Helminthes, Humains, Jeune adulte, Mâle, Variation génétique, Wuchereria bancrofti.
Wicri :
- geographic : Papouasie-Nouvelle-Guinée.

English descriptors

KwdEn :
- Adolescent, Adult, Animals, Child, DNA, Helminth (chemistry), DNA, Helminth (genetics), Electron Transport Complex IV (genetics), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (parasitology), Female, Genetic Variation, Haplotypes, Helminths (classification), Helminths (genetics), Helminths (isolation & purification), Humans, Male, Mitochondrial Proteins (genetics), Molecular Sequence Data, Papua New Guinea (epidemiology), Sequence Analysis, DNA, Wuchereria bancrofti (classification), Wuchereria bancrofti (genetics), Wuchereria bancrofti (isolation & purification), Young Adult.
MESH :
- chemical , chemistry : DNA, Helminth.
- chemical , genetics : DNA, Helminth, Electron Transport Complex IV, Mitochondrial Proteins.
- geographic , epidemiology : Papua New Guinea.
- classification : Helminths, Wuchereria bancrofti.
- epidemiology : Elephantiasis, Filarial.
- genetics : Helminths, Wuchereria bancrofti.
- isolation & purification : Helminths, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Child, Female, Genetic Variation, Haplotypes, Humans, Male, Molecular Sequence Data, Sequence Analysis, DNA, Young Adult.

Abstract

Background

Wuchereria bancrofti (Wb) is the primary causative agent of lymphatic filariasis (LF). Our studies of LF in Papua New Guinea (PNG) have shown that it is possible to reduce the prevalence of Wb in humans and mosquitoes through mass drug administration (MDA; diethylcarbamazine with/without ivermectin). While MDAs in the Dreikikir region through 1998 significantly reduced prevalence of Wb infection, parasites continue to be transmitted in the area.

Methods

We sequenced the Wb mitochondrial Cytochrome Oxidase 1 (CO1) gene from 16 people infected with Wb. Patients were selected from 7 villages encompassing both high and moderate annual transmission potentials (ATP). We collected genetic data with the objectives to (i) document contemporary levels of genetic diversity and (ii) distinguish between populations of parasites and hosts across the study area.

Principle Findings

We discovered 109 unique haplotypes currently segregating in the Wb parasite population, with one common haplotype present in 15 out of 16 infections. We found that parasite diversity was similar among people residing within the same village and clustered within transmission zones. For example, in the high transmission area, diversity tended to be more similar between neighboring villages, while in the moderate transmission area, diversity tended to be less similar.

Conclusions

In the Dreikikir region of PNG there are currently high levels of genetic diversity in populations of Wb. High levels of genetic diversity may complicate future MDAs in this region and the presence of dominant haplotypes will require adjustments to current elimination strategies.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708868

DOI: 10.1371/journal.pntd.0002308
PubMed: 23875043
PubMed Central: 3708868

Affiliations:

Le document en format XML

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<term>Elephantiasis, Filarial (epidemiology)</term>
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<term>Papua New Guinea (epidemiology)</term>
<term>Sequence Analysis, DNA</term>
<term>Wuchereria bancrofti (classification)</term>
<term>Wuchereria bancrofti (genetics)</term>
<term>Wuchereria bancrofti (isolation & purification)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN des helminthes ()</term>
<term>ADN des helminthes (génétique)</term>
<term>Adolescent</term>
<term>Adulte</term>
<term>Analyse de séquence d'ADN</term>
<term>Animaux</term>
<term>Complexe IV de la chaîne respiratoire (génétique)</term>
<term>Données de séquences moléculaires</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Filariose lymphatique (parasitologie)</term>
<term>Filariose lymphatique (épidémiologie)</term>
<term>Haplotypes</term>
<term>Helminthes ()</term>
<term>Helminthes (génétique)</term>
<term>Helminthes (isolement et purification)</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Papouasie - Nouvelle-Guinée (épidémiologie)</term>
<term>Protéines mitochondriales (génétique)</term>
<term>Variation génétique</term>
<term>Wuchereria bancrofti ()</term>
<term>Wuchereria bancrofti (génétique)</term>
<term>Wuchereria bancrofti (isolement et purification)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA, Helminth</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Helminth</term>
<term>Electron Transport Complex IV</term>
<term>Mitochondrial Proteins</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Papua New Guinea</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Helminths</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Helminths</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN des helminthes</term>
<term>Complexe IV de la chaîne respiratoire</term>
<term>Helminthes</term>
<term>Protéines mitochondriales</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Helminths</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Helminthes</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term>
<term>Papouasie - Nouvelle-Guinée</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Animals</term>
<term>Child</term>
<term>Female</term>
<term>Genetic Variation</term>
<term>Haplotypes</term>
<term>Humans</term>
<term>Male</term>
<term>Molecular Sequence Data</term>
<term>Sequence Analysis, DNA</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>ADN des helminthes</term>
<term>Adolescent</term>
<term>Adulte</term>
<term>Analyse de séquence d'ADN</term>
<term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Haplotypes</term>
<term>Helminthes</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Variation génétique</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Papouasie-Nouvelle-Guinée</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p><italic>Wuchereria bancrofti</italic>
 (Wb) is the primary causative agent of lymphatic filariasis (LF). Our studies of LF in Papua New Guinea (PNG) have shown that it is possible to reduce the prevalence of Wb in humans and mosquitoes through mass drug administration (MDA; diethylcarbamazine with/without ivermectin). While MDAs in the Dreikikir region through 1998 significantly reduced prevalence of Wb infection, parasites continue to be transmitted in the area.</p>
</sec>
<sec><title>Methods</title>
<p>We sequenced the Wb mitochondrial Cytochrome Oxidase 1 (CO1) gene from 16 people infected with Wb. Patients were selected from 7 villages encompassing both high and moderate annual transmission potentials (ATP). We collected genetic data with the objectives to (i) document contemporary levels of genetic diversity and (ii) distinguish between populations of parasites and hosts across the study area.</p>
</sec>
<sec><title>Principle Findings</title>
<p>We discovered 109 unique haplotypes currently segregating in the Wb parasite population, with one common haplotype present in 15 out of 16 infections. We found that parasite diversity was similar among people residing within the same village and clustered within transmission zones. For example, in the high transmission area, diversity tended to be more similar between neighboring villages, while in the moderate transmission area, diversity tended to be less similar.</p>
</sec>
<sec><title>Conclusions</title>
<p>In the Dreikikir region of PNG there are currently high levels of genetic diversity in populations of Wb. High levels of genetic diversity may complicate future MDAs in this region and the presence of dominant haplotypes will require adjustments to current elimination strategies.</p>
</sec>
</div>
</front>
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</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Papouasie-Nouvelle-Guinée</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Ohio</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Ohio"><name sortKey="Small, Scott T" sort="Small, Scott T" uniqKey="Small S" first="Scott T." last="Small">Scott T. Small</name>
</region>
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<name sortKey="Bun, Krufinta" sort="Bun, Krufinta" uniqKey="Bun K" first="Krufinta" last="Bun">Krufinta Bun</name>
<name sortKey="Kazura, James W" sort="Kazura, James W" uniqKey="Kazura J" first="James W." last="Kazura">James W. Kazura</name>
<name sortKey="Ramesh, Akshaya" sort="Ramesh, Akshaya" uniqKey="Ramesh A" first="Akshaya" last="Ramesh">Akshaya Ramesh</name>
<name sortKey="Reimer, Lisa" sort="Reimer, Lisa" uniqKey="Reimer L" first="Lisa" last="Reimer">Lisa Reimer</name>
<name sortKey="Thomsen, Edward" sort="Thomsen, Edward" uniqKey="Thomsen E" first="Edward" last="Thomsen">Edward Thomsen</name>
<name sortKey="Tisch, Daniel J" sort="Tisch, Daniel J" uniqKey="Tisch D" first="Daniel J." last="Tisch">Daniel J. Tisch</name>
<name sortKey="Zimmerman, Peter A" sort="Zimmerman, Peter A" uniqKey="Zimmerman P" first="Peter A." last="Zimmerman">Peter A. Zimmerman</name>
</country>
<country name="Papouasie-Nouvelle-Guinée"><noRegion><name sortKey="Reimer, Lisa" sort="Reimer, Lisa" uniqKey="Reimer L" first="Lisa" last="Reimer">Lisa Reimer</name>
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<name sortKey="Baea, Manasseh" sort="Baea, Manasseh" uniqKey="Baea M" first="Manasseh" last="Baea">Manasseh Baea</name>
<name sortKey="Bockarie, Moses J" sort="Bockarie, Moses J" uniqKey="Bockarie M" first="Moses J." last="Bockarie">Moses J. Bockarie</name>
<name sortKey="Siba, Peter" sort="Siba, Peter" uniqKey="Siba P" first="Peter" last="Siba">Peter Siba</name>
<name sortKey="Thomsen, Edward" sort="Thomsen, Edward" uniqKey="Thomsen E" first="Edward" last="Thomsen">Edward Thomsen</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Bockarie, Moses J" sort="Bockarie, Moses J" uniqKey="Bockarie M" first="Moses J." last="Bockarie">Moses J. Bockarie</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
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   |type=    RBID
   |clé=     PMC:3708868
   |texte=   Population Genetics of the Filarial Worm Wuchereria bancrofti in a Post-treatment Region of Papua New Guinea: Insights into Diversity and Life History
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Population Genetics of the Filarial Worm Wuchereria bancrofti in a Post-treatment Region of Papua New Guinea: Insights into Diversity and Life History

Population Genetics of the Filarial Worm Wuchereria bancrofti in a Post-treatment Region of Papua New Guinea: Insights into Diversity and Life History

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